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Increases were dose-dependent and generally greater in females in males across indications. In clinical trials in 1885 children and adolescents, galactorrhea was reported in 0. Juvenile Animal Studies Juvenile dogs were treated for 40 weeks with oral risperidone doses of 0. Decreased bone length and density were seen, with a no-effect dose of 0. In addition, a delay in Risperdal best For Order maturation was seen at all doses in Risperdal best For Order males and females. In a study in which juvenile rats were treated with oral risperidone from days 12 to 50 of age, a reversible impairment of performance in a test of learning and memory was seen, in females only, with a no-effect dose of 0.

No other consistent effects on neurobehavioral or reproductive development were seen up to the Risperdal bestest For Order testable dose 1. This dose produced plasma levels AUC of risperidone plus paliperidone which were about two thirds of those observed in humans at the MRHD. Other reported clinical experience has not identified differences in responses between elderly and younger patients.

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While Risperdal best For Order patients exhibit a greater tendency to orthostatic hypotension, its risk in the elderly may be minimized by limiting the initial dose to 0. Monitoring of orthostatic vital signs should be considered in patients for whom this is of concern.

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Manifestations can include confusion, obtundation, postural instability with frequent falls, extrapyramidal symptoms, and Risperdal best For Order features consistent with neuroleptic malignant syndrome. One case, involving an estimated overdose of 240 mg, was associated with hyponatremia, hypokalemia, prolonged QT, and widened QRS. Another case, involving an estimated overdose of 36 mg, was associated with a seizure.

Provide supportive care including close medical supervision and monitoring. Ensure an Risperdal best For Order airway, oxygenation, and ventilation. Monitor cardiac rhythm and vital signs. Use supportive and symptomatic measures. Hypersensitivity reactions, including anaphylactic reactions and angioedema, have been reported in patients treated with risperidone and in patients treated with paliperidone.

Paliperidone is a metabolite of risperidone. Pharmacokinetics Absorption Risperidone is well absorbed. Plasma concentrations of risperidone, its major metabolite, 9-hydroxyrisperidone, and risperidone Risperdal best For Order 9-hydroxyrisperidone are dose proportional over the dosing range of 1 to 16 mg Risperdal best For Order 0. Peak concentrations of 9-hydroxyrisperidone occurred at about 3 hours in extensive metabolizers, and 17 hours in poor metabolizers. Steady-state concentrations of risperidone are reached in 1 day in extensive metabolizers and would be expected to reach steady-state in about 5 days in poor metabolizers.

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Steady-state concentrations of 9-hydroxyrisperidone are reached in 5-6 days measured in extensive metabolizers. Food Effect Food does not affect either the rate or extent of absorption of risperidone. Distribution Risperidone is rapidly distributed.

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  • In a study in which juvenile rats were treated with oral risperidone from days 12 to 50 of age, a reversible impairment of performance in a test of learning and memory was seen, in females only, with a no-effect dose of 0.
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